Promethazine Promethazine is often a phenothiazine by-product, which differs structurally in the antipsychotic phenothiazines through the presence of a branched facet chain and no ring substitution.
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The codeine and promethazine in Promethazine HCl and Codeine Phosphate Oral Solution may boost the frequency of seizures in patients with seizure Problems, and could enhance the chance of seizures developing in other clinical configurations linked to seizures.
Promethazine and codeine combination is employed To alleviate cough, runny or stuffy nose, sneezing, or other signs brought on by allergy symptoms or maybe the typical chilly.
g., Individuals with evidence of elevated intracranial pressure or Mind tumors), Promethazine HCl and Codeine Phosphate Oral Alternative may perhaps cut down respiratory generate, along with the resultant CO2 retention can further more enhance intracranial strain. Additionally, opioids produce adverse reactions that will obscure the medical system of sufferers with head injuries.
Clinical scientific tests of promethazine hydrochloride and codeine phosphate syrup did not consist of enough numbers of subjects aged 65 and over to find out whether they answer in another way from younger subjects. Other described scientific encounter hasn't identified dissimilarities in responses amongst the aged and younger sufferers.
Consequences about the Cardiovascular Process Codeine produces peripheral vasodilation which can cause orthostatic hypotension or syncope. Manifestations of histamine launch and/or peripheral vasodilation might include pruritus, flushing, pink eyes and perspiring and/or orthostatic hypotension.
Choose this medication by mouth with or without the need of food as directed by your physician, commonly every four to six hrs as necessary. This medication may be taken with food stuff if tummy upset occurs. Drink lots of fluids whenever you use this medication Unless of course if not directed by your medical doctor.
This can occur Even when you consider Promethazine Hydrochloride and Codeine Phosphate Oral Alternative specifically as prescribed by your Health care service provider. Your chance of addiction, abuse, and misuse is elevated for those who or perhaps a family member features a history of drug or Liquor abuse or dependancy, or psychological health problems.
It is soluble in h2o and freely soluble in Liquor. It's got a molecular excess weight of 320.88, a molecular formulation of C17H20N2S•HCI, and the next structural formula:
Narcotic analgesics bring about histamine release, which seems to generally be answerable for wheals or urticaria often viewed at the positioning of injection on parenteral administration.
This products may well include inactive substances, which might trigger allergic reactions or other problems. Check with your pharmacist for more aspects.
Narcotic analgesics or cough suppressants, such as codeine, should not be Utilized in asthmatic sufferers (see CONTRAINDICATIONS). Nor Promethazine codeine syrup should really they be used in acute febrile health issues connected to productive cough or in Persistent respiratory disease where by interference with capability to obvious the tracheobronchial tree of secretions would've a deleterious impact on the client's respiratory function.
are Expecting or approach to become Expecting. Promethazine Hydrochloride and Codeine Phosphate Oral Resolution can hurt your unborn infant. See “What exactly is A very powerful data I ought to find out about Promethazine Hydrochloride and Codeine Phosphate Oral Solution?” are breastfeeding or intend to breastfeed. Codeine passes into your breast milk and might cause critical side effects in the toddler which includes greater sleepiness, respiratory troubles (respiratory despair), and Loss of life. It's not regarded if promethazine can pass into your breast milk.